Bone Abstracts

The aim was to explore whether osteoporosis in humans influences the morphological status of the cartilage and subchondral bone, and relationship between macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone. Femoral heads were obtained from 68 patients with osteoporosis (OP) and hip OA (OP, n=56; OA, n=12) during hip surgery. Evaluation of the cartilage degeneration was done by Mankin g...

Deceased donor kidneys are exposed to cold ischemic insult, which makes them particularly susceptible to the effects of cold ischemic injury during hypothermic preservation resulting in high rates of delayed graft function. Although cold storage reduces cellular oxygen demand, ischemia causes the rapid depletion of adenosine triphosphate and accumulation of toxic substances leading to cell death. BMP-7 is a valuable reagent in a field of tissue regeneration and preservation un...

Introduction: The RANKL/RANK/OPG system has a key role in bone metabolism. Beyond its role in bone loss, its importance was also documented during inflammation which occurrs in inflammatory bowel disease (IBD). The aim of this study was to investigate the expression of the receptor activator of NF-κB ligand (RANKL) and its receptors RANK as well as its decoy receptor osteoprotegerin (OPG) in the colon during experimantal IBD and following BMP7 or corticosteroid therapy.</...